… Regulation of longevity by bile acids was first observed in Little mice, … The increased levels
of bile acids in these long-lived mice … Increased total bile acid levels have also been observed …

… /− mice (95), it is still not fully established how FXR signaling keeps hepatic fat deposits in
check. While a comparative study in liver- and intestine-specific Fxr −/− mice demonstrate that …

… of longevity, which is induced in the long-lived transgenic C. … of bile acids in longevity
regulation was first revealed through the transcriptome and biochemical analysis of the Little mice, …

… lifespan are known, but general principles of lifespan exten… ) analyses of mice subjected to
8 longevity interventions. We … (GHRKO, Little mice, and Snell and Ames dwarf mice). The latter …

… exists in long-lived mice, we examined if oxylipins were differentially regulated in Ames dwarf
mice. … To determine which of these signaling lipids could be secreted from the BAT of Ames …

… (that is cool for mice), the diminutive long-lived GH-related mutants … signaling in the liver
[91]. Moreover, treating progeroid … To what extent bile acids can impact BAT and longevity is …

… and extend life-span and health-span by an integrated signaling … and regulate energy and
homeostasis of bile acids, glucose, lipid, … These long-lived dwarf mice share many phenotypic …

… of bacterially deprived (BD) worms, which are long-lived due … associated with longevity
interventions in mice have also … of bacterial degradation of bile acids by metformin may be linked …

… bile acid transport with no known role in Cd transport. These … longevity, we measured hepatic
and renal Cd in long-lived … as rapamycin can suppress hepatic Nrf2 signaling [22], which in …

… in long-lived Little mice, Ames dwarf mice, Snell dwarf mice, … through detoxifying toxic bile
acids. We supplemented … The signals were detected and analysed using an Odyssey Two-…